When the Lynx pulled to within five points with 4:32 left in third quarter, the Chicago Sky's Sylvia Fowles scored seven consecutive points to put the Sky up 10.
After that the Sky rolled the rest of the way to finish out a 73-58 win, to make it two in a row and improve to 2-4.
Jia Perkins chipped in 10 points for the Sky. It was the first time she scored in double figures in 2010. She also had three steals and a pair of rebounds.
Fowles ended up with 18 points and three blocked shots.
The Sky led by as many as 14 in the first half and were able to extend that lead to 21 in the fourth quarter.
Lindsay Whalen scored 11 points as the Lynx fell to 1-5 on the season. Minnesota turned the ball over 16 times, the Sky had 10 turnovers.
Chicago's bench had another solid performance. After scoring 34 points against the Storm on Thursday, the Sky bench accounted for 32 points.
The Sky play next at Atlanta on Friday at 6pm CDT.